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Want to know more about Opioids?

An Opioid is a chemical substance that has a morphine like action in the body. Opioid's can be classified as natrual, semi-synthetic, and fully-synthetic.

Natural opioid's include morphine, codeine, thebaine, and oripavine. Semi-sythetic opioids include hydromorphone, hydrocodone, oxycodone, and heroin. Fully-synthetic opioids include fentanyl, pethidine, methadone, and propoxyphene.

Opioid's bind to specific opioid receptors in the central nervous system and in other tissues.


Medical Usage

Opioids are medications that are derived from opium, which is collected from the seed pods of opium poppies. Many synthetic, or man-made, opioids are also available, as are semi-synthetics, which are made by changing the chemical structure of opium.

Opioid medications, also known as narcotics, are most commonly used to treat moderate to severe pain. Some less-potent forms are also used to treat conditions like coughing or diarrhea. They can come in a variety of forms, from tablets and capsules to patches, injectables and suppositories. Some commonly prescribed medications that fall into this category include:

  • Morphine, also known as MS Contin or Kadian
  • Oxycodone, found in Percocet and Percodan and Oxycontin
  • Codeine, found in Tylenol #3 and many prescription cough syrups
  • Hydromorphone, known as Dilaudid
  • Fentanyl, also known as Duragesic in its patch form and Actiq as a transmucosal lozenge
  • Hydrocodone, found in Vicodin and Lortab
  • Methadone, a potent pain killer that is also used to treat heroin addiction
  • Meperidine, also known as Demerol


Opioids at Work

Opioids work in the body by attaching to the opioid receptors. These receptors are found in the gastrointestinal tract, along the spinal cord and in the brain. The body stops perceiving pain when these receptors are blocked.

Another effect of opioids is the feeling of euphoria that is often associated with them. Many people abuse opioid medications specifically to get this feeling and opioid addiction is a severe problem. It is estimated that approximately 9 percent of people have used opioid medications for a purpose other than the intended one.

Many people who abuse opioids are unaware of the dangers these medications can pose. Opioids are nervous system depressants. This means that they slow down many of the body's normal functions, including breathing. This can be extremely dangerous, especially when the medication is used in people who already have decreased respiratory function, or when mixed with other medications or alcohol. The symptoms of an opioid overdose include breathing that is slow and shallow, skin that has a bluish tone, coma or even death. Pregnant women who use opioid medications run the risk of delivering the baby prematurely or giving birth to an addicted infant who must go through the painful and dangerous process of withdrawal.

Opioid Side Effects

Opioids have many other side effects, other than the feeling of euphoria. They are often known to cause constipation and people who take long-acting or timed-release forms of the medications, such as Oxycontin, MS Contin and fentanyl patches are often prescribed a stool softener alongside to keep this side effect from creating a problem. Other common side effects are a loss of sex drive, irregularities in the menstrual cycle and mood swings.


Opioid Withdrawls

Opioid medications taken over a long period of time or for a chronic condition also have the effect of making the body become dependent on them. When this happens, even if it does not lead to addiction, the body experiences withdrawal symptoms. These symptoms can be severe and dangerous. Some of the symptoms found during withdrawal from opioids include:

  • Edginess and anxiety
  • Weepiness
  • Diarrhea
  • Cramping
  • Cravings
  • Insomnia
  • Muscle aches
  • Flu-like symptoms
  • Nausea and vomiting

It generally takes regular use over time before a person becomes physically dependent on the medication, but there is no set time. It's completely dependent on the individual and several other factors, such as which medication is being taken, the strength of the medication, how accustomed the patient is to taking opioid medications and the route of administration.

As the body becomes more accustomed to the drug, the patient will find that more and more medication is required to help achieve the same effect. It can be a fine line for the doctor and patient to walk, as they try to use enough medication to effectively control the pain, while keeping physical dependence to a minimum. There is no reason, however, for a patient to suffer unduly. Part of a doctor's job is to keep pain under control. If this means higher doses of opioid drugs, this should be done and the physical dependence aspect can be dealt with later.

A doctor who has prescribed opioids to treat a temporary condition, for example pain following surgery, will help the patient slowly wean down from the medication to prevent these withdrawal symptoms from becoming troublesome. Often, other medications, such as clonidine -- a medication normally used to treat blood pressure -- are used to help the patient manage symptoms.





Learn More About Opioid's:



American Association for the Treatment of Opioid Dependence

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What is Buprenorphine?
 Buprenorphine is an FDA approved opioid addiction treatment. Currently Subutex® & Suboxone® are the only Buprenorphine medications approved by the FDA. Buprenorphine itself is opioid itself, but the maximal effects are less than other more dangerous opioid agonist like methadone and herion. By producing enough agonist, individuals taking Buprenophine that have become addicted to other opioids are able to discontinue abuse with minimized withdrawl side-effects. In 1965, K.W. Bentley discovered the class of compounds synthesized from an alkaloid of thebaine, the opium poppy plant, known as Papaver somniferum. Among these semi-synthetic compounds is Buprenorphine - the first in a series of opioid agonists. Many were more than 1000 times more effective than the analgesic, morphine. In the 1980s, Reckitt & Colman, today known as Reckitt Benckiser, introduced Buprenorphine hydrochloride for sale. Buprenorphine, an analgesic, was first made in sublingual tablets of 0.2 mg (Temgesic). It was also made as an injectable of 0.3 mg/ml (Buprenex). Read More...

What is Suboxone®?
 Suboxone® is the first narcotic drug available for prescription from a doctor's office for use in the treatment of opioid dependence under the Drug Addiction Treatment Act of 2000 or DATA 2000. The primary active ingredient in Suboxone is Buprenorphine, which itself is a partial opioid agonist. This means the the opioid effects and withdrawal symptoms from Buprenorphine are less than other full opioid agonists such as heroin, methadone, morphine, oxycodone, hydrocodone, codeine, and others. Suboxone, taken as sublingual tablets or "under the tongue", has been shown to help in suppressing opioid withdrawal symptoms, decrease illicit opioid cravings and use, and under the correct supervision can help with overcoming an opioid dependence. Suboxone comes in 2mg and 8mg sizes of sublingual tablet form. Suboxone contains naloxone, which blocks the effects of medicines and drugs like methadone, morphine, and heroin. This is added to prevent people from injecting Suboxone and improper use of the medication. Injecting naloxone can cause withdrawal symptoms. Suboxone is the most commonly prescribed medication and given to patients during the maintenance phase of treatment. Subutex is typically given during the first couple of treatment. Because Suboxone has a lower potential for overdose and abuse, unlike methadone, Certified Doctors are able to prescribe take home supplies of Suboxone in certain circumstances. Read More...

The Benefits of Medication Assisted Treatment for Opioid Addiction
 Since 1949, the 12-step program developed by Alcoholics Anonymous has been the dominant way we think about facing and fighting addiction. Many people have successfully used this community- and willpower-based approach to escaping addiction. However, countless others have tried it, and relapsed. With the powerful hold that opioid addiction has on so many people in America, it’s time to face addiction with an equally powerful—and proven—method: medication-assisted treatment (or MAT). MAT is the practice of using drugs like suboxone and subutex to help people dependent on painkillers gradually ease themselves off their addiction. While these treatments have been available for many years, there is a stigma to relying on these medications to help fight addiction rather than the traditional willpower and community approach of a 12-step program. Here are five benefits to using an MAT approach to ending opioid dependency:
1. MAT is proven to have better results than conventional programs alone.
2. MAT stops withdrawal symptoms so patients can live a normal life.
3. MAT is flexible, allowing medication to be taken at home or in a clinic
4. MAT offers multiple drugs (like suboxone and buprenorphine) to find what works for you
5. It’s easy to find an MAT/suboxone provider near you Read More...